Doctor's Data is open, fully operational, and we can drop ship kits directly to patients. More updates here.

NEW: Podcast & Webinar just added to GI360.com

Podcast

Understanding the GI360 Stool Test: an interview with David Quig, PhD, VP of Scientific Support from Doctor's Data and Laura Stirling, Regenerus Laboratories

Webinar

Interpreting and Applying GI360 Test Data: Identifying the 3 Stages of GI Dysfunction by Dan Kalish, DC and Julia Malkowski, ND, DC

 

NEW: Schedule a video or phone meeting now with your Doctor's Data account representative. We can assist with new account set up, test profile questions, sample report tours, pricing questions, staff education and more.

We are also offering re-broadcasts of previous webinars for practitioners to attend, with live interactive support from your account representative. The next webinar re-broadcast is Wednesday, April 29 at 12 PM Pacific Time. We invite you to watch a presentation by Virginia Osborne ND, "IV Therapies, Treatments and Strategies: GI and Heavy Metal Case Studies." Register here.

 

Laboratory, Endocrine, & Neurotransmitter Symposium

August 28-30, 2020

Bellevue, WA

Gain additional clinical insight and treatment considerations to evaluate some of the most prevalent and challenging conditions that patients present with, including depression, anxiety, altered mental focus and stamina, sexual dysfunction, sleep disturbances, addictions and dependencies, weight management, and chronic disease. Get notified when registration goes live!

 

Gastrointestinal Dysbiosis Impacts Immune Function

 

By Julia Malkowski ND, DC | April 28, 2020

The immune system and gut microbiota have a symbiotic relationship. The abundance and diversity of the microbiota play a significant role in the immune response beyond the immediate gastrointestinal tract. Multiple mechanisms are involved in the intricate web of connections between immune responses and our gut bacteria. A cascade of events initiated by microbial derived metabolites play a significant role in modulation of immune function. To accurately address immune function, one must consider the microbiota based on multiple mechanisms that are involved in the intricate web of connections between immune responses and our gut bacteria. A thorough assessment of the microbial community to necessitate restoration of normobiosis is a valid approach to optimal immune function.  


The gut microbiota has been shown to influence both local and systemic immune responses. The DNA of commensal bacteria has been shown to regulate colonic effector T-cell responses. However, the microbiota’s influence over the immune system isn’t confined to the gastrointestinal tract. Commensal bacteria have been shown to promote hematopoiesis in bone marrow progenitor cells, which then enter systemic circulation. Regulation of antigen presenting cells response is under the influence of the microbiota. E. coli species have been shown to directly promote plasma cell differentiation as well as stimulate lymph node macrophages to produce plasma cell growth factors. Commensal bacteria have been shown to influence the response of monocytes to pathogens, which in turn influences neutrophil response.

Immune cells and the gut microbiota have a distinct relationship. Dysbiotic microbiota abundance has been associated with decreased Th1 and Th17 antigen responses. The microbiota plays an important role in the regulation of T-cells. Germ free (GF) mice display a reduced number of Th1 and Th17 cells, and less gut-associated lymphoid tissue (GALT). When GF mice are intubated with Clostridium species, a cascade of events increased Th17 cell number and release of IL-22 in the small intestine.

Microbial abundance and diversity play a role in immune function. Bacteroides fragilis has been shown to induce Tregs and production of IL-10 via microbial derived metabolites. Clostridium has been shown to promote T-cells. Diversity of Clostridium species within the microbiota has been shown to support optimal Treg cell functions. The quintessential short chain fatty acid, butyrate that is produced by key saccharolytic commensal species has been shown to regulate the size and function of T-reg cells. Decreased abundance of the key butyrate producing bacteria such as and Lacnospiraceae spp. and F. prausnitzii may contribute to disease pathogenesis.

The gut microbiota has profound influences on systemic immune functions. Microbiome abundance and diversity play a significant role in the immune response beyond the immediate gastrointestinal tract. When addressing immune function, it is prudent to include a gut microbiota component. Assessing and restoring normobiosis is an integral component of intervention to support optimal immune function.


References

Belkaid Y, Hand TW. 2014. Role of the microbiota in immunity and inflammation. Cell157: 121–141. https://doi.org/10.1016/j.cell.2014.03.011 

Collins, N., & Belkaid, Y. (2018). Do the Microbiota Influence Vaccines and Protective Immunity to Pathogens? Engaging Our Endogenous Adjuvants. Cold Spring Harbor perspectives in biology, 10(2), a028860. https://doi.org/10.1101/cshperspect.a028860 

Kim, C.H. (2018), Immune regulation by microbiome metabolites. Immunology, 154: 220-229. doi:10.1111/imm.12930 

Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017). Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunological reviews, 279(1), 70–89. https://doi.org/10.1111/imr.12567 

Wellness Wednesday Webinar Series

Melatonin: Synthesis, Sleep and Supplementation Overview

By: Krista Anderson Ross, ND | May 6th, 2020

In this month's webinar, you will the synthesis and various roles of melatonin, obtain current testing and assessment strategies, and Discuss melatonin supplementation options and guidelines. Attendees will also be treated to actual case examples as well as a bonus of a brief review of literature of melatonin’s immune modulating and anti-viral properties, and potential implications for COVID-19. Sign up today!

Webinar

Brain Aging in the Menopausal Woman: Effects on Moods, Memory and Botanical Solutions

by Tori Hudson, ND | May 19, 2020 at 1 PM PST


The aging brain in perimenopausal and postmenopausal women comes with metabolic changes, neurotransmitter changes, vascular changes and more. All of these changes contribute to the unique role of hormones in moods and memory. Select botanicals have some very important impacts and implications in these changes and have a clinical role in prevention and management. To be discussed: Bacopa, saffron, curcumin, St. John's wort, gotu kola, lemon balm, rhodiola.


Objectives:

1) Provide an overview of the brain changes in peri and postmenopausal women

2) Provide an overview of the ramifications of these changes in terms of mood and cognition

3) Instruct attendees on uses of select herbs for these clinical manifestations including efficacy, safety, indications, contraindications and dosages


A live Q&A will follow the presentation.

Disclaimer: All information given about health conditions, treatment, products, and dosages are for educational purposes only and do not constitute medical advice.