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Laboratory, Endocrine, & Neurotransmitter Symposium

14.5 CMEs

Online Only

August 28-30, 2020


Gain additional clinical insight and treatment considerations to evaluate some of the most prevalent and challenging conditions that patients present with, including depression, anxiety, altered mental focus and stamina, sexual dysfunction, sleep disturbances, addictions and dependencies, weight management, and chronic disease. Register today at the early bird price of $379. Additional discounts available for a 2-pack of tickets (one for you, one for a colleague.)

 

Wellness Wednesday Webinar Series

Comprehensive Hormone Health for Men

By: Heather Hydzik, ND

July 1st, 2020

In this month's webinar, you will understand the role of testosterone in men’s health, understand andropause and the health impacts of "Low T", and review the roles of estrogen and progesterone in men’s health. Attendees will also explore therapies to address hormonal changes in men, and discuss the risks and benefits of testosterone replacement therapy (TRT). Sign up today!

 

Allopregnanolone for mood, brain, and HPA axis support

 

By Heather Hydzik, ND | June 23, 2020

Allopregnanolone is a progesterone metabolite known for its anxiolytic, antidepressant, neuroprotective, and neurogenic effects. When progesterone is supplemented via the oral route a large proportion is metabolized by the liver to allopregnanolone. This metabolite is a positive modulator of GABA action on the GABAA receptor, the main inhibitory neurotransmitter in the brain, which usually can improve mood, calm anxiety, and support sleep.  

Low allopregnanolone levels have been associated with major depression, anxiety disorders, premenstrual dysphoric disorder (PMDD), and Alzheimer’s disease. Low levels of allopregnanolone during pregnancy have been associated with depression and a recent study found that infusion of allopregnanolone can rapidly treat postpartum depression (PPD). This led to the 2019 FDA approval of Brexanolone, a synthetic form of allopregnanolone, to treat PPD. Allopregnanolone is also being studied as a potential therapy for Alzheimer’s Disease. Murine research has shown that allopregnanolone can increase generation of new brain cells, reduce formation of beta-amyloid plaques, and improve cognitive function; human trials are underway. 

Allopregnanolone targets one of the common underlying factors involved in disorders like depression, anxiety and insomnia – dysregulated response to stress. Findings from rat research suggest that allopregnanolone may help regulate HPA axis reactivity. Pretreatment of rats with allopregnanolone can decrease the stress-induced release of cortisol and ACTH. In humans, allopregnanolone levels increase in response to stimulation by CRH or ACTH, which may be a mechanism to help protect the brain during stress and to help restore a calm state. 

Note that certain women may have paradoxical reactions to allopregnanolone exposure due to differences in the subunit on the GABA receptor called α-4. When too much α-4 is produced, the receptor’s capacity to use GABA is blunted, which can cause increased anxiety and worsened mood for some. Up to 8% of women exposed to allopregnanolone paradoxically experience significant negative mood symptoms, so be sure to pay close attention to patient response to oral progesterone therapy. 

Because of its calming and mood-lifting effects, oral progesterone supplementation is a consideration for treating anxiety, depression and insomnia. Oral progesterone can be used concurrently with physiological doses of topical progesterone without causing excessively high salivary levels.

References

Schüle C, Nothdurfter C, Rupprecht R. The role of allopregnanolone in depression and anxiety. Prog Neurobiol. 2014 Feb;113:79-87. doi: 10.1016/j.pneurobio.2013.09.003. Epub 2013 Nov 8.

Biggio G, Pisu MG, Biggio F, Serra M. Allopregnanolone modulation of HPA axis function in the adult rat. Psychopharmacology (Berl). 2014 Sep;231(17):3437-44.

Maguire J. Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression. Front. Cell. Neurosci., 8 March 2019. https://doi.org/10.3389/fncel.2019.00083

Chen S, Wang JM, Irwin RW, Yao J, Liu L, Brinton RD. Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. PLoS One. 2011;6(8):e24293. doi: 10.1371/journal.pone.0024293. Epub 2011 Aug 30.

Free Webinar

The Neurotransmitter Connection to Stress: Case Studies and Clinical Applications

By: Scott Theirl, DC

July 15th, 2020

Case studies are always a great opportunity to solidify clinical applications. At this time, it seems appropriate to focus on the stress that patients are reporting. Responses to stress vary patient by patient. Insomnia, fatigue, anxiousness, depressive episodes, poor attention, increased pain, GI distress, and weight gain are some of the most common presentations to our offices. Looking for common threads is crucial to supporting patients on their road to health. The nervous system uses neurotransmitters all day, every day, and stress places an increased demand on these neurotransmitter systems. Join Scott Theirl DC as he discusses why neurotransmitters, along with hormones such as cortisol, are key to understanding your patient's stress responses and symptoms. The basic concepts involved in neurotransmitter interpretation will be reviewed. Case studies will then be utilized to personalize therapeutic recommendations. A Q&A session will follow the main presentation.

Disclaimer: All information given about health conditions, treatment, products, and dosages are for educational purposes only and do not constitute medical advice.